Deciphering Fatty Acid Synthase Inhibition-Triggered Metabolic Flexibility in Prostate Cancer Cells through Untargeted Metabolomics

Fatty acid synthase (FAS) is a key enzyme involved in de novo lipogenesis that produces lipids that are necessary for cell growth and signal transduction, and it is known to be overexpressed, especially in cancer cells. Although lipid metabolism alteration is an important metabolic phenotype in canc...

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Main Authors: Ju Eun Oh, Byung Hwa Jung, Jinyoung Park, Soosung Kang, Hyunbeom Lee
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-11-01
Colecção:Cells
Assuntos:
fatty acid synthase
metabolomics
metabolic flexibility
enzyme inhibition
glycerophospholipid metabolism
Acesso em linha:https://www.mdpi.com/2073-4409/9/11/2447
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