Perturbation of Ephrin Receptor Signaling and Glutamatergic Transmission in the Hypothalamus in Depression Using Proteomics Integrated With Metabolomics

Hypothalamic dysfunction is a key pathological factor in inflammation-associated depression. In the present study, isobaric tags for relative-absolute quantitation (iTRAQ) combined with mass spectrometry and gas chromatography-mass spectrometry (GC-MS) were employed to detect the proteomes and metab...

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Detalhes bibliográficos
Main Authors: Yu Wu, Zhenhong Wei, Yonghong Li, Chaojun Wei, Yuanting Li, Pengfei Cheng, Hui Xu, Zhenhao Li, Rui Guo, Xiaoming Qi, Jing Jia, Yanjuan Jia, Wanxia Wang, Xiaoling Gao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-12-01
Colecção:Frontiers in Neuroscience
Assuntos:
depression
inflammation
hypothalamus
omics
Ephrin receptor signaling
glutamatergic transmission
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnins.2019.01359/full
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