Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells

The use of cell-based therapies may be helpful in eradicating cancer cells. Here, the authors generate bifunctional mesenchymal stem cells and demonstrate their therapeutic efficacy in glioblastoma patient-derived models.

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Autors principals: Deepak Bhere, Sung Hugh Choi, Pim van de Donk, David Hope, Kiki Gortzak, Amina Kunnummal, Jasneet Khalsa, Esther Revai Lechtich, Clemens Reinshagen, Victoria Leon, Nabil Nissar, Wenya Linda Bi, Cheng Feng, Hongbin Li, Yu Shrike Zhang, Steven H. Liang, Neil Vasdev, Walid Ibn Essayed, Pablo Valdes Quevedo, Alexandra Golby, Naima Banouni, Anna Palagina, Reza Abdi, Brian Fury, Stelios Smirnakis, Alarice Lowe, Brock Reeve, Arthur Hiller, E. Antonio Chiocca, Glenn Prestwich, Hiroaki Wakimoto, Gerhard Bauer, Khalid Shah
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2022-05-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-022-30558-3
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