Immunomodulatory effects of intraoperative dexmedetomidine on T helper 1, T helper 2, T helper 17 and regulatory T cells cytokine levels and their balance: a prospective, randomised, double-blind, dose-response clinical study

Abstract Background The ratio of T helper 1 (Th1) to T helper 2 (Th2) as well as T helper 17 (Th17) to regulatory T cells (Treg) represents the state and direction of immune response. Recent studies demonstrated that dexmedetomidine reduced the secretion of inflammatory cytokines. We performed this...

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Detalhes bibliográficos
Main Authors: Jae-Myeong Lee, Hyo-Jo Han, Won-Kyu Choi, Subin Yoo, Soojin Baek, Jaemin Lee
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-11-01
Colecção:BMC Anesthesiology
Assuntos:
Cytokines
Dexmedetomidine
Surgery
T cell
Th1/Th2 balance
T17/Treg balance
Acesso em linha:http://link.springer.com/article/10.1186/s12871-018-0625-2
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