Autophagy Correlates with the Therapeutic Responsiveness of Malignant Pleural Mesothelioma in 3D Models.

Malignant pleural mesothelioma is a highly chemoresistant solid tumor. We have studied this apoptotic resistance using in vitro and ex vivo three-dimensional models, which acquire a high level of chemoresistance that can be reduced by PI3K/mTOR inhibitors. Here, we investigate the activity of GDC-09...

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Huvudupphovsmän: Dario Barbone, Carlo Follo, Nohemy Echeverry, Victor H Gerbaudo, Astero Klabatsa, Raphael Bueno, Emanuela Felley-Bosco, V Courtney Broaddus
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science (PLoS) 2015-01-01
Serie:PLoS ONE
Länkar:http://europepmc.org/articles/PMC4540424?pdf=render
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