Systematic analysis of IL-6 as a predictive biomarker and desensitizer of immunotherapy responses in patients with non-small cell lung cancer

Abstract Background Cytokines have been reported to alter the response to immune checkpoint inhibitors (ICIs) in patients with the tumor in accordance with their plasma concentrations. Here, we aimed to identify the key cytokines which influenced the responses and stimulated resistance to ICIs and t...

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Bibliographic Details
Main Authors: Chengming Liu, Lu Yang, Haiyan Xu, Sufei Zheng, Zhanyu Wang, Sihui Wang, Yaning Yang, Shuyang Zhang, Xiaoli Feng, Nan Sun, Yan Wang, Jie He
Format: Artigo
Language:Inglês
Published: BMC 2022-05-01
Series:BMC Medicine
Subjects:
NSCLC
Immune checkpoint inhibitors
IL-6
Clinical response
Resistance
Online Access:https://doi.org/10.1186/s12916-022-02356-7
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