Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice

Abstract Background Abdominal aortic aneurysm (AAA) is a relatively common and often fatal condition. A major histopathological hallmark of AAA is the severe degeneration of aortic media with loss of vascular smooth muscle cells (VSMCs), which are the main source of extracellular matrix (ECM) protei...

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Main Authors: Chung-Huang Chen, Hua-Hui Ho, Wei-Cheng Jiang, Wai-Sam Ao-Ieong, Jane Wang, Alexander N. Orekhov, Igor A. Sobenin, Matthew D. Layne, Shaw-Fang Yet
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Journal of Biomedical Science
Assuntos:
Abdominal aortic aneurysm
Cysteine-rich protein 2
Vascular smooth muscle cells
Collagen III
Matrix metalloproteinase 2
Acesso em linha:https://doi.org/10.1186/s12929-022-00808-z
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