Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer’s Disease

Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. Deficits in cholinergic neurotransmitters are linked closely with the progression of Alzheimer’s disease (AD), which is a neurodegenerative disorder characteri...

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Bibliographic Details
Main Authors: Minky Son, Chanin Park, Shailima Rampogu, Amir Zeb, Keun Woo Lee
Format: Artigo
Language:Inglês
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
acetylcholinesterase
Alzheimer’s disease
molecular docking
molecular dynamics simulation
pharmacophore modeling
Online Access:https://www.mdpi.com/1422-0067/20/4/1000
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