Direct Conversion of Fibroblasts to Megakaryocyte Progenitors

Current sources of platelets for transfusion are insufficient and associated with risk of alloimmunization and blood-borne infection. These limitations could be addressed by the generation of autologous megakaryocytes (MKs) derived in vitro from somatic cells with the ability to engraft and differen...

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Autori principali: Julian Pulecio, Oriol Alejo-Valle, Sandra Capellera-Garcia, Marianna Vitaloni, Paula Rio, Eva Mejía-Ramírez, Ilaria Caserta, Juan A. Bueren, Johan Flygare, Angel Raya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016-10-01
Serie:Cell Reports
Soggetti:
transdifferentiation
lineage conversion
Fanconi anemia
thrombocytopenia
platelets
Accesso online:http://www.sciencedirect.com/science/article/pii/S221112471631275X
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