Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1

Summary: Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease. Astrocytic factors are known to contribute to motor neuron degeneration and death in ALS. However, the role of astrocyte in promoting motor neuron protein aggregation, a disease hallmark of ALS, rem...

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Main Authors: Pratibha Tripathi, Natalia Rodriguez-Muela, Joseph R. Klim, A. Sophie de Boer, Sahil Agrawal, Jackson Sandoe, Claudia S. Lopes, Karolyn Sassi Ogliari, Luis A. Williams, Matthew Shear, Lee L. Rubin, Kevin Eggan, Qiao Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-08-01
Colecção:Stem Cell Reports
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213671117302710
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