Resistance Mechanisms and Barriers to Successful Immunotherapy for Treating Glioblastoma

Glioblastoma (GBM) is inevitably refractory to surgery and chemoradiation. The hope for immunotherapy has yet to be realised in the treatment of GBM. Immune checkpoint blockade antibodies, particularly those targeting the Programme death 1 (PD-1)/PD-1 ligand (PD-L1) pathway, have improved the progno...

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Main Authors: Jason Adhikaree, Julia Moreno-Vicente, Aanchal Preet Kaur, Andrew Mark Jackson, Poulam M. Patel
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-01-01
Colecção:Cells
Assuntos:
glioblastoma
immunotherapy
resistance mechanisms
programme death-1
immune checkpoint blockade
Acesso em linha:https://www.mdpi.com/2073-4409/9/2/263
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