The Leading Role of the Immune Microenvironment in Multiple Myeloma: A New Target with a Great Prognostic and Clinical Value

Multiple myeloma (MM) is a plasma cell (PC) malignancy whose development flourishes in the bone marrow microenvironment (BMME). The BMME components’ immunoediting may foster MM progression by favoring initial immunotolerance and subsequent tumor cell escape from immune surveillance. In this dynamic...

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Main Authors: Vanessa Desantis, Francesco Domenico Savino, Antonietta Scaringella, Maria Assunta Potenza, Carmela Nacci, Maria Antonia Frassanito, Angelo Vacca, Monica Montagnani
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2022-04-01
Serija:Journal of Clinical Medicine
Teme:
multiple myeloma
bone marrow niche
immune escape
immune exhaustion
immune checkpoint inhibitors
immune microenvironment
Online dostop:https://www.mdpi.com/2077-0383/11/9/2513
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