Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates

Cardiomyocytes from human induced pluripotent stem cells (hiPSC-CMs) are the most promising human source with preserved genetic background of healthy individuals or patients. This study aimed to establish a systematic procedure for exploring development of hiPSC-CM functional output to predict genet...

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Hauptverfasser: Josè Manuel Pioner, Lorenzo Santini, Chiara Palandri, Daniele Martella, Flavia Lupi, Marianna Langione, Silvia Querceto, Bruno Grandinetti, Valentina Balducci, Patrizia Benzoni, Sara Landi, Andrea Barbuti, Federico Ferrarese Lupi, Luca Boarino, Laura Sartiani, Chiara Tesi, David L. Mack, Michael Regnier, Elisabetta Cerbai, Camilla Parmeggiani, Corrado Poggesi, Cecilia Ferrantini, Raffaele Coppini
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2019-08-01
Schriftenreihe:International Journal of Molecular Sciences
Schlagworte:
human induced pluripotent stem cells
cardiomyocytes
fluorescence
maturation
action potential
calcium handling
hydrogels
long-term culture
Online Zugang:https://www.mdpi.com/1422-0067/20/15/3799
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