A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets

Abstract Background Medical digital twins are computational disease models for drug discovery and treatment. Unresolved problems include how to organize and prioritize between disease-associated changes in digital twins, on cellulome- and genome-wide scales. We present a dynamic framework that can b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xinxiu Li, Eun Jung Lee, Sandra Lilja, Joseph Loscalzo, Samuel Schäfer, Martin Smelik, Maria Regina Strobl, Oleg Sysoev, Hui Wang, Huan Zhang, Yelin Zhao, Danuta R. Gawel, Barbara Bohle, Mikael Benson
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2022-05-01
Cyfres:Genome Medicine
Pynciau:
ScRNA-seq
Inflammatory diseases
Upstream regulators
Multicellular network models
Mynediad Ar-lein:https://doi.org/10.1186/s13073-022-01048-4
Tagiau: Ychwanegu Tag
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