TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1/M2 phenotype

Abstract Background Toll-like receptors (TLRs) and macrophages play an important role in rheumatoid arthritis (RA). Currently, it is not clear whether inflammatory M1 or anti-inflammatory M2 predominate among the resident macrophages in the synovium. In the present study, we set out to investigate t...

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Bibliografski detalji
Glavni autori: Lilian Quero, Edveena Hanser, Tobias Manigold, André N. Tiaden, Diego Kyburz
Format: Artigo
Jezik:Inglês
Izdano: BMC 2017-11-01
Serija:Arthritis Research & Therapy
Teme:
TLRs
Monocytes
Macrophages
Cytokines
Gene expression
CD markers
Online pristup:http://link.springer.com/article/10.1186/s13075-017-1447-1
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