Inherited DNA Repair Gene Mutations in Men with Lethal Prostate Cancer

Germline variants in DNA repair genes are associated with aggressive prostate cancer (PrCa). The aim of this study was to characterize germline variants in DNA repair genes associated with lethal PrCa in Finnish and Swedish populations. Whole-exome sequencing was performed for 122 lethal and 60 unse...

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Detalhes bibliográficos
Main Authors: Tommi Rantapero, Tiina Wahlfors, Anna Kähler, Christina Hultman, Johan Lindberg, Teuvo L. J. Tammela, Matti Nykter, Johanna Schleutker, Fredrik Wiklund
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-03-01
Colecção:Genes
Assuntos:
prostate cancer
dna repair genes
lethal cancer
Acesso em linha:https://www.mdpi.com/2073-4425/11/3/314
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