Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity

A trypsin inhibitor isolated from tamarind seed (TTI) has satietogenic effects in animals, increasing the cholecystokinin (CCK) in eutrophy and reducing leptin in obesity. We purified TTI (pTTI), characterised, and observed its effect upon CCK and leptin in obese Wistar rats. By HPLC, and after ampl...

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Bibliografiska uppgifter
Huvudupphovsmän: Amanda Fernandes de Medeiros, Izael de Sousa Costa, Fabiana Maria Coimbra de Carvalho, Sumika Kiyota, Beatriz Blenda Pinheiro de Souza, Daniel Nogoceke Sifuentes, Raphael Paschoal Serquiz, Bruna Leal Lima Maciel, Adriana Ferreira Uchôa, Elizeu Antunes dos Santos, Ana Heloneida de Araújo Morais
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis Group 2018-01-01
Serie:Journal of Enzyme Inhibition and Medicinal Chemistry
Ämnen:
Tamarind
antitryptic
Wistar rats
CCK
Länkar:http://dx.doi.org/10.1080/14756366.2017.1419220
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