Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity

A trypsin inhibitor isolated from tamarind seed (TTI) has satietogenic effects in animals, increasing the cholecystokinin (CCK) in eutrophy and reducing leptin in obesity. We purified TTI (pTTI), characterised, and observed its effect upon CCK and leptin in obese Wistar rats. By HPLC, and after ampl...

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Xehetasun bibliografikoak
Egile Nagusiak: Amanda Fernandes de Medeiros, Izael de Sousa Costa, Fabiana Maria Coimbra de Carvalho, Sumika Kiyota, Beatriz Blenda Pinheiro de Souza, Daniel Nogoceke Sifuentes, Raphael Paschoal Serquiz, Bruna Leal Lima Maciel, Adriana Ferreira Uchôa, Elizeu Antunes dos Santos, Ana Heloneida de Araújo Morais
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis Group 2018-01-01
Saila:Journal of Enzyme Inhibition and Medicinal Chemistry
Gaiak:
Tamarind
antitryptic
Wistar rats
CCK
Sarrera elektronikoa:http://dx.doi.org/10.1080/14756366.2017.1419220
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