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Structure-based predictive models for allosteric hot spots.

In allostery, a binding event at one site in a protein modulates the behavior of a distant site. Identifying residues that relay the signal between sites remains a challenge. We have developed predictive models using support-vector machines, a widely used machine-learning method. The training data s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Omar N A Demerdash, Michael D Daily, Julie C Mitchell
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2009-10-01
Schriftenreihe:PLoS Computational Biology
Online Zugang:http://europepmc.org/articles/PMC2748687?pdf=render
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