Safety and Efficacy of PD-1/PD-L1 Inhibitors in Cancer Patients With Preexisting Autoantibodies

BackgroundProgrammed cell death protein-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitors therapy is now a routine scheme in cancers. However, the effect of preexisting autoantibodies on the safety and efficacy of PD-1/PD-L1 inhibitors in cancer patients is not well understood.MethodsThe pres...

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Hauptverfasser: Hui Tang, Ruixuan Geng, Xiuxiu Xu, Yingyi Wang, Jiaxin Zhou, Shulan Zhang, Lin Zhao, Mei Guan, Chunmei Bai
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2022-05-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
programmed cell death-1
antinuclear antibody
anti-Ro52 antibody
antithyroid antibody
immune-related adverse events
Online Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.893179/full
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