Data-Driven Mathematical Model of Apoptosis Regulation in Memory Plasma Cells

Memory plasma cells constitutively produce copious amounts of antibodies, imposing a critical risk factor for autoimmune disease. We previously found that plasma cell survival requires secreted factors such as APRIL and direct contact to stromal cells, which act in concert to activate NF-κB- and PI3...

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Hauptverfasser: Philipp Burt, Rebecca Cornelis, Gustav Geißler, Stefanie Hahne, Andreas Radbruch, Hyun-Dong Chang, Kevin Thurley
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-05-01
Schriftenreihe:Cells
Schlagworte:
plasma cells
mathematical model
apoptosis
immunological memory
cell signaling
Online Zugang:https://www.mdpi.com/2073-4409/11/9/1547
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