Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis

Liver fibrosis occurs following inflammation triggered by the integrated actions of activated liver-resident macrophages (Kupffer cells) and hepatic stellate cells (HSCs), and the multiplicity of these mechanisms complicates drug therapy. Here, we demonstrate that the selective bromodomain and extra...

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Main Authors: Rong Fu, Shi-Jia Zu, Yan-Jun Liu, Jia-Cheng Li, Wen-Zhen Dang, Li-Ping Liao, Li-Ping Liu, Pan-Yu Chen, He-Ming Huang, Kang-Hui Wu, Bing Zhou, Qin Pan, Cheng Luo, Yuan-Yuan Zhang, Guang-Ming Li
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2022-04-01
Colecção:Bioengineered
Assuntos:
BET inhibitor
macrophage
hepatic stellate cell
inflammation
fibrosis
Acesso em linha:https://www.tandfonline.com/doi/10.1080/21655979.2022.2066756
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