Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults

Abstract Background Microfibrillar‐associated protein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen‐related protein superfamily, which plays multifaceted roles in innate immunity and normal endothelial function. It has been proposed that MFAP4 promotes the development of a...

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Main Authors: Benjamin Hoffmann‐Petersen, Raymond Suffolk, Jens Jakob Herrche Petersen, Thomas Houmann Petersen, Kirsten Arendt, Arne Høst, Susanne Halken, Grith Lykke Sorensen, Lone Agertoft
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2019-09-01
Colecção:Immunity, Inflammation and Disease
Assuntos:
adolescent
asthma
biomarkers
child
microfibrillar‐associated protein 4
Acesso em linha:https://doi.org/10.1002/iid3.254
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id oai:doaj.org-article:be38a67cc6ff48ef9ce4f2496e845c96
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spelling oai:doaj.org-article:be38a67cc6ff48ef9ce4f2496e845c962022-04-13T00:55:00ZengWileyImmunity, Inflammation and Disease2050-45272019-09-017315015910.1002/iid3.254Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adultsBenjamin Hoffmann‐Petersen0Raymond Suffolk1Jens Jakob Herrche Petersen2Thomas Houmann Petersen3Kirsten Arendt4Arne Høst5Susanne Halken6Grith Lykke Sorensen7Lone Agertoft8Hans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkDepartment of Pediatrics Hospital of Southern Jutland Aabenraa DenmarkDepartment of Pediatrics Hospital of Southern Jutland Esbjerg DenmarkDepartment of Pediatrics Hospital of Southern Jutland Kolding DenmarkDepartment of Pediatrics Hospital of Southern Jutland Aabenraa DenmarkHans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkHans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkInstitute of Molecular Medicine University of Southern Denmark Odense DenmarkHans Christian Andersen Children's Hospital Odense University Hospital Odense DenmarkAbstract Background Microfibrillar‐associated protein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen‐related protein superfamily, which plays multifaceted roles in innate immunity and normal endothelial function. It has been proposed that MFAP4 promotes the development of asthma in vivo and proasthmatic pathways of bronchial smooth muscle cells in vitro. The aim of this study was to investigate the significance of serum MFAP4 in adolescents and young adolescents with persistent asthma. Methods Prospective, observational study including adolescents and young adults (age 11‐27 years) previously diagnosed with asthma during childhood 2003 to 2005 (0‐15 years) at the four pediatric outpatient clinics in the Region of Southern Denmark (n = 449). Healthy controls were recruited at follow‐up (n = 314). Detection of serum MFAP4 was performed by AlphaLISA technique. Results Current asthma was associated to a 14% higher mean level of serum MFAP4 compared with controls (expβ 1.14, 95% confidence intervals [CI], 1.05‐1.23) and a 6% higher mean level compared with subjects with no current asthma (expβ 1.06, 95% CI, 0.99‐1.13). No association was found at follow‐up between serum MFAP4 and self‐reported atopic symptoms (other than asthma), Asthma Control Test‐score, fractional exhaled nitric oxide (FeNO), nor to flow rate at 1 second, forced vital capacity, and forced expiratory flow 25% to 75%, response to short‐acting beta 2 agonist or mannitol. Conclusions We found a significantly higher mean level of serum MFAP4 in adolescent and young adults with mild to moderate asthma compared with healthy controls but no association to FeNO and lung function nor to the response to short‐acting beta 2 agonist or mannitol. The result supports the hypothesis that MFAP4 plays a role in the pathogenesis of asthma although the marker did not demonstrate any obvious potential as an asthma biomarker in adolescents and young adults with asthma. To understand the possible proasthmatic functions of MFAP4, further investigation in specific asthma phenotypes and the underlying molecular mechanisms is warranted.https://doi.org/10.1002/iid3.254adolescentasthmabiomarkerschildmicrofibrillar‐associated protein 4
institution DOAJ
collection Directory of Open Access Journals
language Inglês
format Artigo
author Benjamin Hoffmann‐Petersen
Raymond Suffolk
Jens Jakob Herrche Petersen
Thomas Houmann Petersen
Kirsten Arendt
Arne Høst
Susanne Halken
Grith Lykke Sorensen
Lone Agertoft
spellingShingle Benjamin Hoffmann‐Petersen
Raymond Suffolk
Jens Jakob Herrche Petersen
Thomas Houmann Petersen
Kirsten Arendt
Arne Høst
Susanne Halken
Grith Lykke Sorensen
Lone Agertoft
Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults
Immunity, Inflammation and Disease
adolescent
asthma
biomarkers
child
microfibrillar‐associated protein 4
author_facet Benjamin Hoffmann‐Petersen
Raymond Suffolk
Jens Jakob Herrche Petersen
Thomas Houmann Petersen
Kirsten Arendt
Arne Høst
Susanne Halken
Grith Lykke Sorensen
Lone Agertoft
author_sort Benjamin Hoffmann‐Petersen
title Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults
title_short Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults
title_full Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults
title_fullStr Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults
title_full_unstemmed Microfibrillar‐associated protein 4 in serum is associated with asthma in Danish adolescents and young adults
title_sort microfibrillar‐associated protein 4 in serum is associated with asthma in danish adolescents and young adults
publisher Wiley
series Immunity, Inflammation and Disease
issn 2050-4527
publishDate 2019-09-01
description Abstract Background Microfibrillar‐associated protein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen‐related protein superfamily, which plays multifaceted roles in innate immunity and normal endothelial function. It has been proposed that MFAP4 promotes the development of asthma in vivo and proasthmatic pathways of bronchial smooth muscle cells in vitro. The aim of this study was to investigate the significance of serum MFAP4 in adolescents and young adolescents with persistent asthma. Methods Prospective, observational study including adolescents and young adults (age 11‐27 years) previously diagnosed with asthma during childhood 2003 to 2005 (0‐15 years) at the four pediatric outpatient clinics in the Region of Southern Denmark (n = 449). Healthy controls were recruited at follow‐up (n = 314). Detection of serum MFAP4 was performed by AlphaLISA technique. Results Current asthma was associated to a 14% higher mean level of serum MFAP4 compared with controls (expβ 1.14, 95% confidence intervals [CI], 1.05‐1.23) and a 6% higher mean level compared with subjects with no current asthma (expβ 1.06, 95% CI, 0.99‐1.13). No association was found at follow‐up between serum MFAP4 and self‐reported atopic symptoms (other than asthma), Asthma Control Test‐score, fractional exhaled nitric oxide (FeNO), nor to flow rate at 1 second, forced vital capacity, and forced expiratory flow 25% to 75%, response to short‐acting beta 2 agonist or mannitol. Conclusions We found a significantly higher mean level of serum MFAP4 in adolescent and young adults with mild to moderate asthma compared with healthy controls but no association to FeNO and lung function nor to the response to short‐acting beta 2 agonist or mannitol. The result supports the hypothesis that MFAP4 plays a role in the pathogenesis of asthma although the marker did not demonstrate any obvious potential as an asthma biomarker in adolescents and young adults with asthma. To understand the possible proasthmatic functions of MFAP4, further investigation in specific asthma phenotypes and the underlying molecular mechanisms is warranted.
topic adolescent
asthma
biomarkers
child
microfibrillar‐associated protein 4
url https://doi.org/10.1002/iid3.254
_version_ 1735066804339867648

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