Key Players in the Mutant p53 Team: Small Molecules, Gene Editing, Immunotherapy

The transcription factor p53 is a key tumor suppressor that is inactivated in almost all cancers due to either point mutations in the TP53 gene or overexpression of its negative regulators. The p53 protein is known as the “cellular gatekeeper” for its roles in facilitating DNA repair, cell cycle arr...

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Hlavní autoři: Vitaly Chasov, Regina Mirgayazova, Ekaterina Zmievskaya, Raniya Khadiullina, Aygul Valiullina, Joseph Stephenson Clarke, Albert Rizvanov, Matthias G. J. Baud, Emil Bulatov
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020-08-01
Edice:Frontiers in Oncology
Témata:
p53
mutation
small molecules
adenoviral gene therapy
CRISPR/Cas gene editing
immunotherapy
On-line přístup:https://www.frontiersin.org/article/10.3389/fonc.2020.01460/full
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