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Preliminary Results on the Long-Term Effects of Dextromethorphan on MDMA-Mediated Serotonergic Deficiency and Volumetric Changes in Primates Based on 4-[18F]-ADAM PET/MRI

Alterations to the serotonergic system due to 3,4-methylenedioxymethamphetamine (MDMA) (ecstasy) consumption have been extensively documented. However, knowledge of the reversibility of these neurotoxic effects based on in vivo evaluations of serotonin transport (SERT) availability remains limited....

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Bibliographische Detailangaben
Hauptverfasser: Skye Hsin-Hsien Yeh, Yu-Yeh Kuo, Wen-Sheng Huang, Chuang-Hsin Chiu, Tsung-Hsun Yu, Leo Garcia Flores, Chi-Jung Tsai, Cheng-Yi Cheng, Kuo-Hsing Ma
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2022-05-01
Schriftenreihe:Frontiers in Neuroscience
Schlagworte:
4-[18F]-ADAM PET
MDMA-induced serotonergic deficiency
SERT reversibility
volumetric changes
neuroprotective effects of dextromethorphan
Online Zugang:https://www.frontiersin.org/articles/10.3389/fnins.2022.837194/full
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