Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models

Diverse signaling cues and attendant proteins work together during organogenesis, including craniofacial development. Lip and palate formation starts as early as the fourth week of gestation in humans or embryonic day 9.5 in mice. Disruptions in these early events may cause serious consequences, suc...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kurt Reynolds, Priyanka Kumari, Lessly Sepulveda Rincon, Ran Gu, Yu Ji, Santosh Kumar, Chengji J. Zhou
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2019-02-01
Schriftenreihe:Disease Models & Mechanisms
Schlagworte:
Orofacial clefts
Cleft lip
Cleft palate
Wnt
Bmp
Fgf
Tgfβ
Shh
Retinoic acid
Epigenetics
Crosstalk
Online Zugang:http://dmm.biologists.org/content/12/2/dmm037051
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