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Optimization of levetiracetam dosing regimen in critically ill patients with augmented renal clearance: a Monte Carlo simulation study

Abstract Background Levetiracetam pharmacokinetics is extensively altered in critically ill patients with augmented renal clearance (ARC). Consequently, the dosage regimens commonly used in clinical practice may not be sufficient to achieve target plasma concentrations. The aim of this study is to p...

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Detalhes bibliográficos
Main Authors: Idoia Bilbao-Meseguer, Helena Barrasa, Alicia Rodríguez-Gascón, Eduardo Asín-Prieto, Javier Maynar, José Ángel Sánchez-Izquierdo, María Ángeles Solinís, Arantxazu Isla
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Journal of Intensive Care
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Acesso em linha:https://doi.org/10.1186/s40560-022-00611-w
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