Nonsense-Mediated mRNA Decay: Pathologies and the Potential for Novel Therapeutics

Nonsense-mediated messenger RNA (mRNA) decay (NMD) is a surveillance pathway used by cells to control the quality mRNAs and to fine-tune transcript abundance. NMD plays an important role in cell cycle regulation, cell viability, DNA damage response, while also serving as a barrier to virus infection...

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Bibliographic Details
Main Authors: Kamila Pawlicka, Umesh Kalathiya, Javier Alfaro
Format: Artigo
Language:Inglês
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
nonsense-mediated mrna decay
premature termination codon
cancer
neoantigens
nmd inhibition
Online Access:https://www.mdpi.com/2072-6694/12/3/765
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