Intra-lesional injection of the novel PKC activator EBC-46 rapidly ablates tumors in mouse models.

Intra-lesional chemotherapy for treatment of cutaneous malignancies has been used for many decades, allowing higher local drug concentrations and less toxicity than systemic agents. Here we describe a novel diterpene ester, EBC-46, and provide preclinical data supporting its use as an intra-lesional...

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Autors principals: Glen M Boyle, Marjorie M A D'Souza, Carly J Pierce, Ryan A Adams, Aaron S Cantor, Jenny P Johns, Lidia Maslovskaya, Victoria A Gordon, Paul W Reddell, Peter G Parsons
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2014-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC4182759?pdf=render
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