Dovitinib preferentially targets endothelial cells rather than cancer cells for the inhibition of hepatocellular carcinoma growth and metastasis

<p>Abstract</p> <p>Background</p> <p>Dovitinib is a receptor tyrosine kinase (RTK) inhibitor targeting vascular endothelial growth factor receptors, fibroblast growth factor receptors and platelet-derived growth factor receptor β. Dovitinib is currently in clinical tria...

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Detalhes bibliográficos
Main Authors: Chen Zhi-Yuan, Shi Ming, Peng Li-Xia, Wei Wei, Li Xin-Jian, Guo Zhi-Xing, Li Shu-Hong, Zhong Chong, Qian Chao-Nan, Guo Rong-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2012-12-01
Colecção:Journal of Translational Medicine
Assuntos:
Dovitinib
Endothelial cells
Hepatocellular carcinoma
Tumor growth
Tumor metastasis
Acesso em linha:http://www.translational-medicine.com/content/10/1/245
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