A high-speed congenic strategy using first-wave male germ cells.

BACKGROUND: In laboratory mice and rats, congenic breeding is essential for analyzing the genes of interest on specific genetic backgrounds and for analyzing quantitative trait loci. However, in theory it takes about 3-4 years to achieve a strain carrying about 99% of the recipient genome at the ten...

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Hauptverfasser: Narumi Ogonuki, Kimiko Inoue, Michiko Hirose, Ikuo Miura, Keiji Mochida, Takahiro Sato, Nathan Mise, Kazuyuki Mekada, Atsushi Yoshiki, Kuniya Abe, Hiroki Kurihara, Shigeharu Wakana, Atsuo Ogura
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2009-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC2659429?pdf=render
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