Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks.

Genome-wide association studies (GWAS) are routinely being used to examine the genetic contribution to complex human traits, such as high-density lipoprotein cholesterol (HDL-C). Although HDL-C levels are highly heritable (h(2)∼0.7), the genetic determinants identified through GWAS contribute to a s...

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Autori principali: Stephen D Turner, Richard L Berg, James G Linneman, Peggy L Peissig, Dana C Crawford, Joshua C Denny, Dan M Roden, Catherine A McCarty, Marylyn D Ritchie, Russell A Wilke
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2011-05-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC3092760?pdf=render
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