Emerging Role of HMGB1 in the Pathogenesis of Schistosomiasis Liver Fibrosis

In chronic schistosomiasis, liver fibrosis is linked to portal hypertension, which is a condition associated with high mortality and morbidity. High mobility group box 1 (HMGB1) was originally described as a nuclear protein that functions as a structural co-factor in transcriptional regulation. Howe...

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Main Authors: Amanda R. R. Vicentino, Vitor C. Carneiro, Diego Allonso, Rafael de Freitas Guilherme, Claudia F. Benjamim, Hílton A. M. dos Santos, Fabíola Xavier, Alexandre dos Santos Pyrrho, Juliana de Assis Silva Gomes, Matheus de Castro Fonseca, Rodrigo C. de Oliveira, Thiago A. Pereira, Leandro Ladislau, José R. Lambertucci, Marcelo R. Fantappié
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-09-01
Colecção:Frontiers in Immunology
Assuntos:
schistosomiasis
HMGB1
granuloma
liver fibrosis
drugs therapy
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.01979/full
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