Auto-segmentation and time-dependent systematic analysis of mesoscale cellular structure in β-cells during insulin secretion.

The mesoscale description of the subcellular organization informs about cellular mechanisms in disease state. However, applications of soft X-ray tomography (SXT), an important approach for characterizing organelle organization, are limited by labor-intensive manual segmentation. Here we report a pi...

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Main Authors: Angdi Li, Xiangyi Zhang, Jitin Singla, Kate White, Valentina Loconte, Chuanyang Hu, Chuyu Zhang, Shuailin Li, Weimin Li, John Paul Francis, Chenxi Wang, Andrej Sali, Liping Sun, Xuming He, Raymond C Stevens
格式: Artigo
語言:Inglês
出版: Public Library of Science (PLoS) 2022-01-01
叢編:PLoS ONE
在線閱讀:https://doi.org/10.1371/journal.pone.0265567
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