Multi-omics Analysis of Primary Cell Culture Models Reveals Genetic and Epigenetic Basis of Intratumoral Phenotypic Diversity

Uncovering the functionally essential variations related to tumorigenesis and tumor progression from cancer genomics data is still challenging due to the genetic diversity among patients, and extensive inter- and intra-tumoral heterogeneity at different levels of gene expression regulation, includin...

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Bibliographic Details
Main Authors: Sixue Liu, Zuyu Yang, Guanghao Li, Chunyan Li, Yanting Luo, Qiang Gong, Xin Wu, Tao Li, Zhiqian Zhang, Baocai Xing, Xiaolan Xu, Xuemei Lu
Format: Artigo
Language:Inglês
Published: Elsevier 2019-12-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Intra-individual tumor heterogeneity
Parallel primary culture
Multi-omics
Functional phenotypic diversity
Online Access:http://www.sciencedirect.com/science/article/pii/S1672022920300280
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