Lattice complex assembled by noncompetitive anti-EGFR antibodies regulates actin cytoskeletal reorganization

Abstract Background Recent evidence of clinical trials highlights that the combination of two noncompetitive anti-EGFR antibodies can benefit patients with several cancers. Previous studies propose that a lattice complex assembled by antibodies and EGFR down-regulates surface EGFR by rapid internali...

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Detalhes bibliográficos
Main Authors: Dianshuai Huang, Tianqi Lu, Xingyu Du, Xi Xi, Xin Zhang, Xitian Zhang, Haoran Zhang, Fei Sun
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-04-01
Colecção:Cancer Cell International
Assuntos:
EGFR
Lattice complex
Noncompetitive antibody combination
Cytoskeleton
PIP2
Acesso em linha:http://link.springer.com/article/10.1186/s12935-020-01204-z
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