Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques

This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particle motion within the DCM were characterized using P...

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Autori principali: Konstantinos Stamatopoulos, Sharad Karandikar, Mark Goldstein, Connor O’Farrell, Luca Marciani, Sarah Sulaiman, Caroline L. Hoad, Mark J. H. Simmons, Hannah K. Batchelor
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2020-07-01
Serie:Pharmaceutics
Soggetti:
dynamic colon model (DCM)
colon-specific drug formulations
magnetic resonance imaging (MRI)
positron emission tomography (PET)
in vitro models
dissolution
Accesso online:https://www.mdpi.com/1999-4923/12/7/659
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