Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection

Abstract Spike-mediated entry of SARS-CoV-2 into human airway epithelial cells is an attractive therapeutic target for COVID-19. In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan (GAG) attached to certain me...

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Hauptverfasser: Qi Zhang, Peter Radvak, Juhyung Lee, Yue Xu, Vivian Cao-Dao, Miao Xu, Wei Zheng, Catherine Z. Chen, Hang Xie, Yihong Ye
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2022-04-01
Schriftenreihe:Scientific Reports
Online Zugang:https://doi.org/10.1038/s41598-022-10293-x
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