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Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection
Abstract Spike-mediated entry of SARS-CoV-2 into human airway epithelial cells is an attractive therapeutic target for COVID-19. In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan (GAG) attached to certain me...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2022-04-01
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| Serier: | Scientific Reports |
| Online adgang: | https://doi.org/10.1038/s41598-022-10293-x |
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