Integrated Computational Model of Intracellular Signaling and microRNA Regulation Predicts the Network Balances and Timing Constraints Critical to the Hepatic Stellate Cell Activation Process

Activation and deactivation of hepatic stellate cells (HSCs) is an important mechanism contributing to both healthy liver function and development of liver diseases, which relies on the interplay between numerous signaling pathways. There is accumulating evidence for the regulatory role of microRNAs...

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Main Authors: Lakshmi Kuttippurathu, Austin Parrish, Rajanikanth Vadigepalli
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI AG 2014-10-01
Sraith:Processes
Ábhair:
hepatic stellate cell
microRNA regulation
NF-κB
STAT3
TGF-β
network model
simulation
Rochtain Ar Líne:http://www.mdpi.com/2227-9717/2/4/773
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