Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model.

BACKGROUND:Local inflammation associated with solid tumors commonly results from factors released by tumor cells and the tumor stroma, and promotes tumor progression. Cancer associated fibroblasts comprise a majority of the cells found in tumor stroma and are appealing targets for cancer therapy. He...

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Hauptverfasser: Debbie Liao, Yunping Luo, Dorothy Markowitz, Rong Xiang, Ralph A Reisfeld
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2009-11-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC2775953?pdf=render
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