GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents

A panel of docking scaffolds was developed for the known molecular targets of the anticancer agents, thieno[2,3-b]pyridines, in order to glean insight into their mechanism of action. The reported targets are the copper-trafficking antioxidant 1 protein, tyrosyl DNA phosphodiesterase 1, the colchicin...

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Main Authors: Ayesha Zafar, Suat Sari, Euphemia Leung, Lisa I. Pilkington, Michelle van Rensburg, David Barker, Jóhannes Reynisson
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2017-12-01
Colecção:Molecules
Assuntos:
docking
molecular and homology modelling
drug discovery
chemical space
Acesso em linha:https://www.mdpi.com/1420-3049/22/12/2254
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