Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer’s Disease Through the PINK1/Parkin Pathway

The accumulation of abnormal aggregation of amyloid-β plaques is one of the most distinguishing pathologies of Alzheimer’s disease (AD) and is highly toxic to neurons. Exosomes have demonstrated great potential for AD therapy. However, the impact and underlying mechanism of M2 microglia-derived exos...

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Main Authors: Nan Li, Jun Shu, Xiaoyan Yang, Wenshi Wei, Aijuan Yan
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2022-04-01
סדרה:Frontiers in Cellular Neuroscience
נושאים:
M2 microglia cells
mitophagy
exosomes
Alzheimer’s disease
Aβ treatment
PINK1/Parkin pathway
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fncel.2022.874102/full
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