載入...
Novel 4-Acrylamido-Quinoline Derivatives as Potent PI3K/mTOR Dual Inhibitors: The Design, Synthesis, and in vitro and in vivo Biological Evaluation
A novel structural series of quinoline derivatives were designed, synthesized and biologically evaluated as PI3K/mTOR dual inhibitors upon incorporation of C-4 acrylamide fragment. Consequently, all of them exerted remarkable inhibition against PI3Kα with IC50 values ranging from 0.50 to 2.03 nM. Be...
Na minha lista:
| Main Authors: | , , , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Frontiers Media S.A.
2019-04-01
|
| 叢編: | Frontiers in Chemistry |
| 主題: | |
| 在線閱讀: | https://www.frontiersin.org/article/10.3389/fchem.2019.00236/full |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|