The effect of a loading dose of meropenem on outcomes of patients with sepsis treated by continuous renal replacement: study protocol for a randomized controlled trial

Abstract Background Sepsis and continuous renal replacement therapy (CRRT) are both responsible for the alterations of the pharmacokinetics of antibiotics. For patients with sepsis receiving CRRT, the serum concentrations of meropenem in the early phase (< 48 h) was significantly lower than that...

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Detalhes bibliográficos
Main Authors: Sui-Qing Ni, Wen-Bing Teng, Yong-Hong Fu, Wei Su, Zhi Yang, Jie Cai, Jin-Nuo Xu, Xiao-Ying Deng, Xiang-Fang Liu, Sheng-Nan Fu, Jun Zeng, Chen Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Trials
Assuntos:
Sepsis
Continuous renal replacement therapy (CRRT)
Meropenem
Loading dose
Pharmacokinetic (PK)/pharmacodynamics (PD) target
Clinical cure rate
Acesso em linha:https://doi.org/10.1186/s13063-022-06264-2
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