Differential susceptibility of Onchocerca volvulus microfilaria to ivermectin in two areas of contrasting history of mass drug administration in Cameroon: relevance of microscopy and molecular techniques for the monitoring of skin microfilarial repopulation within six months of direct observed treatment

Abstract Background Ivermectin is an excellent microfilaricide against Onchocerca volvulus. However, in some regions, long term use of ivermectin has resulted in sub-optimal responses to the treatment. More data to properly document the phenomenon in various contexts of ivermectin mass drug administ...

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Main Authors: Raphael Awah Abong, Glory N. Amambo, Patrick W. Chounna Ndongmo, Abdel Jelil Njouendou, Ritter Manuel, Amuam Andrew Beng, Mathias Eyong Esum, Kebede Deribe, Jerome Fru-Cho, Fanny F. Fombad, Theobald Mue Nji, Peter Ivo Enyong, Catherine B. Poole, Kenneth Pfarr, Achim Hoerauf, Clotilde K. S. Carlow, Samuel Wanji
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-10-01
Colecção:BMC Infectious Diseases
Assuntos:
Susceptibility
Monitoring
O. volvulus
Microfilaridemia
Microscopy
Real-time PCR
Acesso em linha:http://link.springer.com/article/10.1186/s12879-020-05444-2
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