Prognostic Significance of Lineage Diversity in Bladder Cancer Revealed by Single-Cell Sequencing

Bladder cancer is the most common malignant tumor of the urinary system. We investigated the clinical implications of cell lineages in bladder cancer by integrating single-cell and bulk transcriptome data. By investigating the single-cell transcriptional profiles of 12,424 cells from normal bladder,...

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Detalhes bibliográficos
Main Authors: Lu Yu, Rixin Hu, Guoyu Peng, Qiuxia Ding, Tao Tao, Song Wu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Genetics
Assuntos:
bladder cancer
intratumoral heterogeneity
single-cell RNA sequencing
deconvolution
cell lineages
prognosis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fgene.2022.862634/full
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