Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration

Abstract Intervertebral disc degeneration (IDD) results from the dysfunction of nucleus pulposus (NP) cells and the exhaustion of NP progenitors (ProNPs). The cellular applications of NP cells during IDD are currently limited due to the lack of in vivo studies showing whether NP cells are heterogene...

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Autores principales: Bo Gao, Bo Jiang, Wenhui Xing, Zaiqi Xie, Zhuojing Luo, Weiguo Zou
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley 2022-05-01
Colección:Advanced Science
Materias:
intervertebral disc
lineage tracing
nucleus pulposus cell atlas
Sc‐RNA seq
stem cell therapy
Acceso en línea:https://doi.org/10.1002/advs.202104888
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