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Alteration in Metabolism and Toxicity of Acetaminophen Upon Repeated Administration in Rats

Our previous studies showed that administration of a subtoxic dose of acetaminophen (APAP) to female rats increased generation of carbon monoxide from dichloromethane, a metabolic reaction catalyzed mainly by cytochrome P450 (CYP) 2E1. In this study we examined the changes in metabolism and toxicity...

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Main Authors: Sun J. Kim, Min Y. Lee, Do Y. Kwon, Sung Y. Kim, Young C. Kim
格式: Artigo
語言:Inglês
出版: Elsevier 2009-01-01
叢編:Journal of Pharmacological Sciences
在線閱讀:http://www.sciencedirect.com/science/article/pii/S1347861319311168
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