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Alteration in Metabolism and Toxicity of Acetaminophen Upon Repeated Administration in Rats
Our previous studies showed that administration of a subtoxic dose of acetaminophen (APAP) to female rats increased generation of carbon monoxide from dichloromethane, a metabolic reaction catalyzed mainly by cytochrome P450 (CYP) 2E1. In this study we examined the changes in metabolism and toxicity...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2009-01-01
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| Colecção: | Journal of Pharmacological Sciences |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S1347861319311168 |
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